This course is designed to provide an update on recent developments in the management of patients with advanced liver disease including chronic hepatitis C, cirrhosis, hepatocellular carcinoma and complications of psychosomatic issues in liver transplant candidates. Through a series of overview lectures and case presentations, participants will become familiar with the use of oral antiviral agents for HCV, the indications and outcomes with adult liver transplantation for HCC, advances in pediatric liver transplantation and potential clinical applications of regenerative medicine in transplantation.