Developing Reproducible Small Animal Models to Better Reflect Lung Fibrosis Pathophysiology

Developing Reproducible Small Animal Models to Better Reflect Lung Fibrosis Pathophysiology is organized by American Physiological Society (APS) and will be held on Jan 11, 2024.

Description:
In this webinar, Elizabeth Redente, PhD, associate professor at National Jewish Health in Denver, will share insights for the study of pulmonary fibrosis using murine models. Her focus will center on expanding the use and relevance of the single-dose bleomycin model of persistent fibrotic disease using genetics, age, sex and repetitive injury. Redente will also discuss the occupational model of silicosis and integrated into model discussion are analytical methods to examine pathophysiology outcomes including pathology, lung physiology using flexiVent, microCT analysis and oxygen saturation. Additionally, Redente will discuss methods of therapeutic intervention and targeted loss of fibroblast populations. 

Key topics include: 

• multiple variables that contribute to successful animal models of fibrosis, including genetics, age, sex, repetitive injury and occupational exposure; 
• an overview of pathophysiology with increased overlap to patient pulmonary fibrosis; 
• an overview of clinically relevant outcomes during persistent fibrosis inducing flexiVent, small animal microCT and pulse oximetry; and  
• using persistent fibrosis models for therapeutic intervention.

Additional details will be posted as soon as information is available.