4th Chromosomal Instability as a Driver of Human Disease Conference

4th Chromosomal Instability as a Driver of Human Disease Conference is organized by Fusion Conferences Ltd and will be held from Oct 07 - 10, 2025 at Hilton Malta, Saint Julian s, Northern Harbour, Malta.

Description:
The maintenance of genome integrity is critical for the suppression of several pathological disorders in humans, including cancer, infertility premature ageing, and neurodegeneration. Destabilization of the genome can occur as a result of several cell intrinsic or extrinsic factors, including errors arising during DNA replication or chromosome segregation, as well as exposure of cells to agents that induce DNA damage. In this conference, we aim to bring together scientists studying DNA replication & repair, chromosome segregation and cellular responses to DNA damage, such as cellular senescence, with those interested in how chromosomal instability can influence human pathology, with a special focus on aging and age-related pathologies. Moreover, we aim to show how high throughput and high content screening methods can be used as a discovery tool both for basic science applications and to identify potential therapeutic modalities.

Key Sessions:

• Pathways for repair of DNA damage and disrupted DNA replication forks
• Screening tools for analysis of genome maintenance pathways and for development of new therapeutics
• Molecular and cellular determinants of aging, with a particular focus on cellular senescence.
• Chromosome instability as a driver of tumorigenesis, neurodegeneration and ageing
• Exploitation of defects in chromosome maintenance in cancer treatment

Educational Need:
Chromosome instability is involved in several human diseases and is a feature of natural ageing. This conference will bridge fundamental studies on the mechanisms by which cells maintain genome stability with applications of these studies aimed at the development of new therapies. Hence, the conference will bridge basic biology and clinical applications in this rapidly advancing field. Attendees should be able to obtain a full picture of the current status of the field, as well as to interact with prominent research leaders driving the clinical application of the latest research.